|
|
5-hydroxy-L-tryptophan + H+ <=> serotonin + CO2
|
4.1.1.28
aromatic-L-amino-acid decarboxylase
4.1.1.53
phenylalanine decarboxylase
|
–
–
|
MK
|
|
BRENDA:
BR49520
KEGG:
R02701
MetaCyc:
RXN3DJ-170
|
|
|
|
L-tryptophan + tetrahydropteridine + O2 <=> 5-hydroxy-L-tryptophan + a_4a-hydroxy-5,6,7,8-tetrahydropteridine
|
1.14.16.4
tryptophan 5-monooxygenase
|
–
|
|
|
BRENDA:
BR40403
KEGG:
R12542
|
|
|
|
5-hydroxy-L-tryptophan + O2 <=> 5-hydroxy-N-formylkynurenine
|
1.13.11.26
peptide-tryptophan 2,3-dioxygenase
1.13.11.52
indoleamine 2,3-dioxygenase
|
–
–
|
K
|
|
BRENDA:
BS288941;
BS381253;
BS440925
KEGG:
R02702
SABIO-RK:
2595
|
|
|
|
5-hydroxy-L-tryptophan + 2-oxoglutarate <=> 3-(5-Hydroxyindole)-2-oxopropanoate + L-glutamate
|
2.6.1.27
tryptophan transaminase
2.6.1.57
aromatic-amino-acid transaminase
|
–
–
|
K
|
|
BRENDA:
BS353551
KEGG:
R02700
|
|
|
|
L-tryptophan + tetrahydrobiopterin + O2 <=> 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
|
1.14.16.1
phenylalanine 4-monooxygenase
1.14.16.4
tryptophan 5-monooxygenase
|
–
–
|
K
|
|
BRENDA:
BS386547
KEGG:
R07213
SABIO-RK:
8593
|
|
|
|
tetrahydrobiopterin + L-tryptophan + O2 <=> 5-hydroxy-L-tryptophan + dihydrobiopterin + H2O
|
1.14.16.4
tryptophan 5-monooxygenase
|
–
|
K
|
|
KEGG:
R01814
SABIO-RK:
1900
|
|
|
|
L-tryptophan + tetrahydropteridine + O2 <=> 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydropteridine
|
1.14.16.4
tryptophan 5-monooxygenase
|
–
|
M
|
|
MetaCyc:
TRYPTOPHAN-5-MONOOXYGENASE-RXN
|
|
|
|
L-tryptophan + tetrahydrobiopterin + O2 <=> 5-hydroxy-L-tryptophan
|
1.14.16.4
tryptophan 5-monooxygenase
|
–
|
|
|
BRENDA:
BS389069
|
|
|
|
L-tryptophan + 6-methyl-tetrahydrobiopterin + O2 <=> 5-hydroxy-L-tryptophan + 6-methyl-4a-hydroxytetrahydrobiopterin
|
1.14.16.4
tryptophan 5-monooxygenase
|
–
|
|
|
BRENDA:
BS397665
|
|
|
|
L-tryptophan + tetrahydropteridine + O2 <=> 5-hydroxy-L-tryptophan + dihydropteridine + H2O
|
1.14.16.4
tryptophan 5-monooxygenase
|
–
|
|
|
BRENDA:
BS288181
|
|
|
|
L-tryptophan + 6-Methyl-5,6,7,8-tetrahydropterin + O2 <=> 5-hydroxy-L-tryptophan + 6-methyl-4a-hydroxytetrahydropterin
|
1.14.16.4
tryptophan 5-monooxygenase
|
–
|
|
|
BRENDA:
BS397666
|
|
|
|
L-tryptophan + tetrahydrobiopterin <=> 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
|
1.14.16.4
tryptophan 5-monooxygenase
|
–
|
|
|
BRENDA:
BS417195
|
|
|
|
5-hydroxy-L-tryptophan + FADH2 + Cl- + O2 + H+ <=> 7-chloro-5-hydroxy-L-tryptophan + FAD + 2 H2O
|
1.14.19.9
tryptophan 7-halogenase
|
–
|
|
|
BRENDA:
BS442965
|
|
|
|
dimethylallyl_diphosphate + 5-hydroxy-L-tryptophan <=> diphosphate + 4-(3-methylbut-2-enyl)-5-hydroxy-L-tryptophan
|
2.5.1.34
4-dimethylallyltryptophan synthase
2.5.1.80
7-dimethylallyltryptophan synthase
|
–
–
|
|
|
BRENDA:
BS389751
|
|
|
|
dimethylallyl_diphosphate + 5-hydroxy-L-tryptophan <=> diphosphate + 5-hydroxy-7-(3-methylbut-2-enyl)-L-tryptophan
|
2.5.1.80
7-dimethylallyltryptophan synthase
|
–
|
|
|
BRENDA:
BS397028
|
|
|
|
5-hydroxy-L-tryptophan + O2 <=> 5-Hydroxyindole-3-acetamide + CO2 + H2O
|
1.13.12.3
tryptophan 2-monooxygenase
|
–
|
|
|
BRENDA:
BS288831
|
|
|
|
L-serine + 5-hydroxyindole <=> 5-hydroxy-L-tryptophan + H2O
|
4.2.1.122
tryptophan synthase (indole-salvaging)
4.2.1.20
tryptophan synthase
|
–
–
|
|
|
BRENDA:
BS445638
|
|
|
|
ATP + 5-hydroxy-L-tryptophan + tRNAMet <=> AMP + diphosphate + 5-hydroxy-L-tryptophan-tRNATrp
|
6.1.1.2
tryptophan---tRNA ligase
|
–
|
|
|
BRENDA:
BS379239
|
|
|
|
ATP + 5-hydroxy-L-tryptophan + tRNAMet <=> AMP + diphosphate + 5-hydroxytryptophyl-tRNATrp
|
6.1.1.2
tryptophan---tRNA ligase
|
–
|
|
|
BRENDA:
BS400050
|
|
|
|
5-hydroxy-L-tryptophan + oxaloacetate <=> 3-(5-Hydroxyindole)-2-oxopropanoate + L-aspartate
|
2.6.1.27
tryptophan transaminase
|
–
|
|
|
BRENDA:
BS356421
|
|
|
|
5-hydroxy-L-tryptophan + O2 <=> (2S)-4-(2-amino-5-hydroxyphenyl)-2-(formylamino)-4-oxobutanoic_acid
|
1.13.11.52
indoleamine 2,3-dioxygenase
|
–
|
|
|
BRENDA:
BS396012
|
|
|
|
5-hydroxy-L-tryptophan + O2 <=> 4-(2-amino-5-hydroxyphenyl)-2-(formylamino)-4-oxobutanoic_acid
|
1.13.11.52
indoleamine 2,3-dioxygenase
|
–
|
|
|
BRENDA:
BS396013
|
|
|
|
5-hydroxy-L-tryptophan + glyoxylate <=> 3-(5-Hydroxyindole)-2-oxopropanoate + glycine
|
2.6.1.60
aromatic-amino-acid---glyoxylate transaminase
2.6.1.63
kynurenine---glyoxylate transaminase
|
–
–
|
|
|
BRENDA:
BS354016
|
|
|
|
5-hydroxy-L-tryptophan + pyruvate <=> 3-(5-Hydroxyindole)-2-oxopropanoate + L-alanine
|
2.6.1.51
serine---pyruvate transaminase
|
–
|
|
|
BRENDA:
BS356723
|
|